A large study conducted at a Veteran’s Administration hospital in Tampla, Florida, found that by including information about hemoglobin, red blood cell count, and serum creatinine together with PSA, they could better predict the outcomes of prostate biopsies.
The study was done in a mainly white population, and since it only assessed men at one location it is difficult to know if the results will be able to be generalized to the entire population of the US or anywhere else.
Nevertheless, this offers a potentially better way to decide who should get a prostate biopsy or not after an elevated serum total PSA concentration is noted.
Reference
Hill OT, Mason TJ, Schwartz SW, Foulis PR (2013) “Improving prostate cancer detection in veterans through the development of a clinical decision rule for prostate biopsy” BMC Urology 13:6. Full text